In this report, we develop a novel approach to assess socio-economic vulnerability to the impacts of climate change that can be replicated across diverse contexts and with limited resources. Specifically, the proposed approach focuses upon incorporating socio-economic information into vulnerability assessments that can assist natural resource managers in formulating adaptation strategies for climate change impacts. The approach uses resource dependency as a proxy for sensitivity to climate change impacts and focuses upon the key agricultural sectors in six natural resource management regions on the east coast of Australia. Five variables associated with socioeconomic vulnerability (percentage of the labour force employed in the agricultural sector, geographic remoteness, socio-economic advantage/disadvantage, economic diversity and age) function as individual lines of evidence that, when combined, help to identify where potential vulnerabilities might be revealed at the sub-regional scale.